ginsenoside Ro, ginsenoside-Ro
| Name | Ginsenoside Ro | ||
| PubChem CID | 11815492 | ||
| Molecular Weight | 957.1g/mol | ||
| Synonyms |
ginsenoside Ro, ginsenoside-Ro |
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| Formula | C₄₈H₇₆O₁₉ | ||
| SMILES | CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)OC6C(C(C(C(O6)C(=O)O)O)O)OC7C(C(C(C(O7)CO)O)O)O)C)C)C2C1)C)C(=O)OC8C(C(C(C(O8)CO)O)O)O)C | ||
| InChI | 1S/C48H76O19/c1-43(2)14-16-48(42(61)67-40-35(58)31(54)29(52)24(20-50)63-40)17-15-46(6)21(22(48)18-43)8-9-26-45(5)12-11-27(44(3,4)25(45)10-13-47(26,46)7)64-41-37(33(56)32(55)36(65-41)38(59)60)66-39-34(57)30(53)28(51)23(19-49)62-39/h8,22-37,39-41,49-58H,9-20H2,1-7H3,(H,59,60)/t22-,23+,24+,25-,26+,27-,28+,29+,30-,31-,32-,33-,34+,35+,36-,37+,39-,40-,41+,45-,46+,47+,48-/m0/s1 | ||
| InChIKey | NFZYDZXHKFHPGA-QQHDHSITSA-N | ||
| CAS Number | 34367-04-9 | ||
| ChEMBL ID | CHEMBL488317 | ||
| ChEBI ID | CHEBI:67981 | ||
| KEGG ID | C17543 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | ZhuJieShen | ||
| Use Part | Rhizome | ||
| Habitat | SiChuan, GuiZhou, YunNan, XiZang, ChongQing, Shaanxi, GanSu, AnHui, ZheJiang, JiangXi, FuJian, HeNan, HuNan, HuBei, GuangXi, XiZang | ||
| Flavor | Sweet, Mildly bitter | ||
| Meridian Tropism | Liver, Spleen, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Araliaceae
-->Genus: Panax
-->Species: Panax japonicus
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| Chineses Pinyin | ZhuJieSanQi | ||
| Use Part | Rhizome | ||
| Habitat | SiChuan, GuiZhou, YunNan, XiZang, ChongQing, ZheJiang, AnHui, HeNan, HuBei, Shaanxi, GanSu, SiChuan, YunNan | ||
| Flavor | Sweet, Bitter | ||
| Meridian Tropism | Liver, Spleen | ||
| Chineses Pinyin | RenShen | ||
| Use Part | Root | ||
| Habitat | JiLin, LiaoNing, HeiLongJiang | ||
| Flavor | Sweet; Slightly Bitter | ||
| Meridian Tropism | Spleen; Lung; Heart; Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Araliaceae
-->Genus: Panax
-->Species: Panax ginseng
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| Pair Name | Ginsenoside Ro, Fluorouracil | |||
| Partner Name | Fluorouracil | |||
| Disease Info | [ICD-11: 2B70] | Esophageal cancer | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Up-regulation | Expression | ATG7 | hsa10533 |
| Down-regulation | Activity | CTSB | hsa1508 | |
| Down-regulation | Activity | CTSD | hsa1509 | |
| Up-regulation | Expression | MAP1LC3A | hsa84557 | |
| Up-regulation | Expression | MAP1LC3B | hsa81631 | |
| Up-regulation | Expression | SQSTM1 | hsa8878 | |
| In Vitro Model | Eca-109 | Esophageal squamous cell carcinoma | Homo sapiens (Human) | CVCL_6898 |
| Result | Ginsenoside Ro suppresses autophagy by interfering with autophagosome-lysosome fusion and lysosomal proteolytic activity via the ESR2-NCF1-ROS axis. Subsequently, such autophagic inhibition reduces CHEK1 degradation, enhances CHEK1-mediated DNA damage checkpoint arrest, and thereby sensitizes tumor cells to 5-Fu-induced cell death. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage checkpoint. Autophagy. 2016;12(9):1593-1613. doi:10.1080/15548627.2016.1192751 | Click |
